Diindolylmethane is formed in the body from plant substances contained in “cruciferous” vegetables such as cabbage, Brussels sprouts, cauliflower, and broccoli. They have different amounts of DIM per capsule (200 or 250mg), and the DIM 250 Complex also contains an array of different supportive ingredients designed to maximize usefulness for use during menopause, including various vegetable powders, Broccoli seed extract, Vitamin D-3, and herbal Dong Quai. After all, any supplement, even if it’s all natural, may have negative side effects. DIM is safe for most individuals, but you may experience some mild detox-like symptoms including: Fatigue; Headache; Nausea; Dark-colored urine; Changes in menstrual cycle The list of side effects below is not a definite one and you should consult your doctor about other potential side effects based on your health condition and possible drug or supplement interactions. It further confirmed results and safety reported from previous studies in adult humans and the adult animal model. DIM has also been shown to favorably alter the ratios of “good” to “bad” estrogen. It may do so in several ways. Higher doses (greater than 100mg) of isolated pure DIM can saturate tissues and block androgen (e.g. DIM Supplement Side Effects and Dosage. DIM blocks the effects of testosterone. testosterone and dihydrotestosterone) receptors and inhibit the protein synthesis induced by the anabolic effects of androgens. Some common side effects that occur following the usage of DIM include a rash with eosinophilia as well as central serous chorioretinopathy . Research seems to show associations between hyponatremia and osteoporosis. DIM – Diindolylmethane is an androgen antagonist! The data from this study indicated that DIM is safe, with no significant side effects found, even with DIM at a dose 10 times higher than that currently used in practice. Learn more about Diindolylmethane uses, benefits, side effects, interactions, safety concerns, and effectiveness. Side effects of DIM supplements are common and may include headaches, dehydration, as well as joint pain, aching, or cracking. Nature's Way DIM Plus is used for estrogen metabolism which is the breakdown of estrogen in the liver attempting to eradicate it. Keep in mind that the safety profile of DIM is relatively unknown, given the lack of well-designed clinical studies. DIM supplements is commonly taken in doses of 100 mg to 200 mg. When taken correctly in the small amounts found in foods, diindolymethane is likely safe. While there are promising benefits that can come with taking DIM, there are some potential side effects to take note. Side Effects. In light of this, are there any DIM adverse consequences? But are the possible benefits worth the risk? Diindolylmethane Side Effects. Diindolylmethane Side Effects Rash, nausea, vomiting, headache, arthralgia and hot flashes have been reported. Diindolylmethane (DIM) is a metabolite of Indole-3-carbinol (I3C), a compound found in cruciferous vegetables including broccoli, cabbage and cauliflower.It is the most studied of all I3C metabolites and is thought to be superior to IC3 as a chemoprotective compound for breast cancer and prostate cancer .. DIM demonstrated anti-inflammatory , antiproliferative and chemopreventive effects … Diindolylmethane may cause a decrease in the amount of sodium in the body . DIM possesses hormone-modulating effects. WebMd.com claims DIM is most likely safe. Hello Marva, DIM 200, and DIM 250 Complex are different supplements. DIM side effects. Diindolylmethane (DIM) reduces the level of "bad estrogen" (16-hydroxyestrone estrogen metabolites) while increasing "good" estrogen (2-hydroxyestrone estrogen metabolites). 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